A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model

A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model

Abstract Purpose In advanced gastric cancer, peritoneal dissemination is a life‐threatening mode of metastasis. Since the treatment options with conventional chemotherapy remain limited, any novel therapeutic strategy that could control such metastasis would improve the outcome of treatment. We rece...

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Bibliographic Details
Main Authors: Hidenori Ando, Masakazu Fukushima, Kiyoshi Eshima, Taichi Hasui, Taro Shimizu, Yu Ishima, Cheng‐Long Huang, Hiromi Wada, Tatsuhiro Ishida
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Cancer Medicine
Subjects:
DFP‐10825
gastric cancer
peritoneal dissemination
RNAi therapeutic
S‐1
thymidylate synthase (TS)
Online Access:https://doi.org/10.1002/cam4.2598

Internet

https://doi.org/10.1002/cam4.2598

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