Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway

Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway

Background: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management of DR. Exosomes, considered as a promising cell-free therapy option, display biological functions similar to those o...

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Main Authors: Nesrine Ebrahim, Heba Elsayed Abd El-Halim, Omayma Kamel Helal, Nahla El-Eraky El-Azab, Omnia A.M. Badr, Amira Hassouna, Hajir A.Al Saihati, Nashwa Hassan Aborayah, Hanan Tawfeek Emam, Hend S. El-wakeel, Mohammad Aljasir, Mohamed El-Sherbiny, Naglaa A.S. Sarg, Gehan Ahmed Shaker, Ola Mostafa, Dina Sabry, Marwa Abdel Kader Fouly, Nicholas Robert Forsyth, Nehal M. Elsherbiny, Rabab F. Salim
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Diabetic retinopathy
Mesenchymal stem cells
Exosomes
Wnt/ b-catenin signaling
Oxidative stress
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222200943X

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http://www.sciencedirect.com/science/article/pii/S075333222200943X

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