Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis

Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis

Abstract Background PI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. Protein phosphorylation is crucial for signaling transduction of this pathway. PIK3CA, encoding the catalytic subunit p110α of PI3K complex, is one of the most frequently mutated oncogenes in human...

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Bibliographic Details
Main Authors: Ting Wang, Longci Sun, Chengkun Chen, Yingchao Zhang, Baoyu He, Yanhua Zhang, Zhenghe Wang, Hanbing Xue, Yujun Hao
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell & Bioscience
Subjects:
PI3K
p110α
Tyrosine phosphorylation
Src
Colorectal cancer
Online Access:https://doi.org/10.1186/s13578-023-01102-7

Internet

https://doi.org/10.1186/s13578-023-01102-7

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