Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis
During the last decades, a dramatic global rise in the prevalence of obesity has become evident. Therefore, effective therapeutic approaches are necessary to help combat this condition. Grape seed is known as a rich source of biologically active polyphenols, which can be used as one of the candidate...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619304335 |
| _version_ | 1819291944249982976 |
|---|---|
| author | Fang Zhou Manwen Yin Yiwen Liu Xue Han Jielong Guo Chenglong Ren Wei Wang Weidong Huang Jicheng Zhan Yilin You |
| author_facet | Fang Zhou Manwen Yin Yiwen Liu Xue Han Jielong Guo Chenglong Ren Wei Wang Weidong Huang Jicheng Zhan Yilin You |
| author_sort | Fang Zhou |
| collection | DOAJ |
| description | During the last decades, a dramatic global rise in the prevalence of obesity has become evident. Therefore, effective therapeutic approaches are necessary to help combat this condition. Grape seed is known as a rich source of biologically active polyphenols, which can be used as one of the candidates to resolve problems associated with obesity. This paper investigated the anti-obesity effects of grape seed flour (GSF) and showed that GSF ameliorated weight gain, hepatic lipid levels and part of the serum profiles. Moreover, GSF increased energy expenditure (EE) and thermogenesis in brown adipose tissue (BAT) in high-fat diet (HFD) induced obese mice. GSF also affected expressions of uncoupling protein 1 (UCP1) and other metabolism-related genes in white adipose tissue (WAT). In conclusion, our results showed that GSF prevented diet-induced obesity in C57BL/6J mice, and suggested that the mechanism responsible was related to the promotion of energy metabolism. |
| first_indexed | 2024-12-24T03:46:41Z |
| format | Article |
| id | doaj.art-7e2cb47038294a32944cb21e556aa542 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:46:41Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-7e2cb47038294a32944cb21e556aa5422022-12-21T17:16:41ZengElsevierJournal of Functional Foods1756-46462019-11-0162Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesisFang Zhou0Manwen Yin1Yiwen Liu2Xue Han3Jielong Guo4Chenglong Ren5Wei Wang6Weidong Huang7Jicheng Zhan8Yilin You9College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, ChinaCollege of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, ChinaCollege of Food Science and Pharmacy, Xinjiang Agricultural University, Nongda East Road 311, Shaibak District, Urumqi 830052, ChinaCollege of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, China; Corresponding authors.College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, China; Corresponding authors.College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Tsinghua East Road 17, Haidian District, Beijing 100083, China; Corresponding authors.During the last decades, a dramatic global rise in the prevalence of obesity has become evident. Therefore, effective therapeutic approaches are necessary to help combat this condition. Grape seed is known as a rich source of biologically active polyphenols, which can be used as one of the candidates to resolve problems associated with obesity. This paper investigated the anti-obesity effects of grape seed flour (GSF) and showed that GSF ameliorated weight gain, hepatic lipid levels and part of the serum profiles. Moreover, GSF increased energy expenditure (EE) and thermogenesis in brown adipose tissue (BAT) in high-fat diet (HFD) induced obese mice. GSF also affected expressions of uncoupling protein 1 (UCP1) and other metabolism-related genes in white adipose tissue (WAT). In conclusion, our results showed that GSF prevented diet-induced obesity in C57BL/6J mice, and suggested that the mechanism responsible was related to the promotion of energy metabolism.http://www.sciencedirect.com/science/article/pii/S1756464619304335ObesityGrape seed flourThermogenesisBrown adipose tissueHigh-fat diet |
| spellingShingle | Fang Zhou Manwen Yin Yiwen Liu Xue Han Jielong Guo Chenglong Ren Wei Wang Weidong Huang Jicheng Zhan Yilin You Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis Journal of Functional Foods Obesity Grape seed flour Thermogenesis Brown adipose tissue High-fat diet |
| title | Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis |
| title_full | Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis |
| title_fullStr | Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis |
| title_full_unstemmed | Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis |
| title_short | Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis |
| title_sort | grape seed flour intake decreases adiposity gain in high fat diet induced obese mice by activating thermogenesis |
| topic | Obesity Grape seed flour Thermogenesis Brown adipose tissue High-fat diet |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619304335 |
| work_keys_str_mv | AT fangzhou grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT manwenyin grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT yiwenliu grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT xuehan grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT jielongguo grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT chenglongren grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT weiwang grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT weidonghuang grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT jichengzhan grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis AT yilinyou grapeseedflourintakedecreasesadipositygaininhighfatdietinducedobesemicebyactivatingthermogenesis |