Population pharmacokinetic-pharmacodynamic model of dexmedetomidine in elderly patients undergoing sedation after abdominal aortic surgery

Population pharmacokinetic-pharmacodynamic model of dexmedetomidine in elderly patients undergoing sedation after abdominal aortic surgery

Background. Dexmedetomidine (DEX) is a widely used sedative agent for treating post-surgery patients. It also acts on hemodynamic parameters like heart rate or cardiac output. This study aimed to develop a pharmacokinetic-pharmacodynamic (PK/PD) model of DEX using bispectral index (BIS) and cardiac...

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Bibliographic Details
Main Authors: Justyna Alicja Ber, Agnieszka Bienert, Paweł Sobczyński, Małgorzata Nowicka, Łukasz Żurański, Marcin Hołysz, Edmund Grześkowiak, Paweł Wiczling
Format: Article
Language:English
Published: Poznan University of Medical Sciences 2023-02-01
Series:Journal of Medical Science
Subjects:
pharmacodynamics
dexmedetomidine
intensive care units
geriatrics
analgosedation
Online Access:https://jms.ump.edu.pl/index.php/JMS/article/view/770

Internet

https://jms.ump.edu.pl/index.php/JMS/article/view/770

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