Population Pharmacokinetics of Amikacin in Patients on Veno-Arterial Extracorporeal Membrane Oxygenation

Population Pharmacokinetics of Amikacin in Patients on Veno-Arterial Extracorporeal Membrane Oxygenation

Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support leads to complex pharmacokinetic alterations, whereas adequate drug dosing is paramount for efficacy and absence of toxicity in critically ill patients. Amikacin is a major antibiotic used in nosocomial sepsis, especially for these...

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Bibliographic Details
Main Authors: Claire Pressiat, Agathe Kudela, Quentin De Roux, Nihel Khoudour, Claire Alessandri, Hakim Haouache, Dominique Vodovar, Paul-Louis Woerther, Alice Hutin, Bijan Ghaleh, Anne Hulin, Nicolas Mongardon
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceutics
Subjects:
extracorporeal membrane oxygenation
sepsis
amikacin
pharmacokinetic/pharmacodynamic modeling
population pharmacokinetics
Bayesian modelization
Online Access:https://www.mdpi.com/1999-4923/14/2/289

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https://www.mdpi.com/1999-4923/14/2/289

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