Role of miR-199a-5p in the post-transcriptional regulation of ABCA1 in response to hypoxia in peritoneal macrophages

Role of miR-199a-5p in the post-transcriptional regulation of ABCA1 in response to hypoxia in peritoneal macrophages

Hypoxia is a crucial factor contributing to maintenance of atherosclerotic lesions. The ability of ABCA1 to stimulate the efflux of cholesterol from cells in the periphery, particularly foam cells in atherosclerotic plaques, is an important anti-atherosclerotic mechanism. The posttranscriptional reg...

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Bibliographic Details
Main Authors: Juan Francisco Aranda, Ana Pérez-García, Marta Torrecilla-Parra, Mario Fernández-de Frutos, Yolanda Martín-Martín, Pedro A. Mateos-Gómez, Virginia Pardo-Marqués, Rebeca Busto, Cristina M. Ramírez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
miRNAs
hypoxia
ABCA1
atherosclerosis
macrophage
cholesterol efflux
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.994080/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.994080/full

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