The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies

The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies

Summary: Although neutralizing monoclonal antibodies (mAbs) against epitopes within the alphavirus E2 protein can protect against infection, the functional significance of non-neutralizing mAbs is poorly understood. Here, we evaluate the activity of 13 non-neutralizing mAbs against Mayaro virus (MAY...

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Bibliographic Details
Main Authors: James T. Earnest, Autumn C. Holmes, Katherine Basore, Matthias Mack, Daved H. Fremont, Michael S. Diamond
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
antibody
neutralization
alphavirus
pathogenesis
protection
epitope
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472100276X

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http://www.sciencedirect.com/science/article/pii/S221112472100276X

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