Visualizing Conformational Space of Functional Biomolecular Complexes by Deep Manifold Learning

Visualizing Conformational Space of Functional Biomolecular Complexes by Deep Manifold Learning

The cellular functions are executed by biological macromolecular complexes in nonequilibrium dynamic processes, which exhibit a vast diversity of conformational states. Solving the conformational continuum of important biomolecular complexes at the atomic level is essential to understanding their fu...

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Bibliographic Details
Main Authors: Zhaolong Wu, Enbo Chen, Shuwen Zhang, Yinping Ma, Youdong Mao
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
AlphaCryo4D
cryogenic electron microscopy
biomolecular complex
structural dynamics
conformational space
energy landscape
Online Access:https://www.mdpi.com/1422-0067/23/16/8872

Internet

https://www.mdpi.com/1422-0067/23/16/8872

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