Engineered Synthetic STxB for Enhanced Cytosolic Delivery

Engineered Synthetic STxB for Enhanced Cytosolic Delivery

Many molecular targets for cancer therapy are located in the cytosol. Therapeutic macromolecules are generally not able to spontaneously translocate across membranes to reach these cytosolic targets. Therefore a strong need exists for tools that enhance cytosolic delivery. Shiga toxin B-subunit (STx...

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Bibliographic Details
Main Authors: Justine Hadjerci, Anne Billet, Pascal Kessler, Gilles Mourier, Marine Ghazarian, Anthony Gonzalez, Christian Wunder, Nesrine Mabrouk, Eric Tartour, Denis Servent, Ludger Johannes
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
synthetic carrier
organic synthesis
endosomal escape
hydrophobic moieties
engineered protein
Online Access:https://www.mdpi.com/2073-4409/12/9/1291

Internet

https://www.mdpi.com/2073-4409/12/9/1291

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