A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice

A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice

Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta (SNpc). α-synuclein (αsyn) has been linked to the pathophysiology of PD, because of its mutations causing familial PD...

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Bibliographic Details
Main Authors: Éva M. Szegő, Ellen Gerhardt, Pawel Kermer, Jörg B. Schulz
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
α-synuclein
MPTP
Dopamine
Regeneration
Striatum
L-DOPA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003305

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http://www.sciencedirect.com/science/article/pii/S0969996111003305

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