Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors

Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors

The overexpression of efflux pumps is one of the causes of multidrug resistance, which leads to the inefficacy of drugs. This plays a pivotal role in antimicrobial resistance, and the most notable pumps are the AcrAB-TolC system (AcrB belongs to the resistance-nodulation-division family) and the Nor...

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Main Authors: Fernando Durães, Andreia Palmeira, Bárbara Cruz, Joana Freitas-Silva, Nikoletta Szemerédi, Luís Gales, Paulo Martins da Costa, Fernando Remião, Renata Silva, Madalena Pinto, Gabriella Spengler, Emília Sousa
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
thioxanthones
antimicrobial resistance
efflux pumps
biofilm
quorum-sensing
Online Access:https://www.mdpi.com/1424-8247/14/6/572

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https://www.mdpi.com/1424-8247/14/6/572

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