Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

Abstract Background Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping functions. However, the mechanism by which MC4R in the arcuate nucleus...

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Bibliographic Details
Main Authors: Hengru Guo, Ying Xin, Saifei Wang, Xiaoning Zhang, Yanqi Ren, Bo Qiao, Hongjiang Li, Jing Wu, Xiao Hao, Lijun Xu, Yushan Yan, Haohao Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Medicine
Subjects:
MC4R
Arcuate nucleus
Kir2.1
Insulin resistance
Energy expenditure
Online Access:https://doi.org/10.1186/s10020-024-00804-z

Internet

https://doi.org/10.1186/s10020-024-00804-z

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