A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imaging of apoptotic cells.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17772-7 |
| _version_ | 1818419920758636544 |
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| author | Nicole D. Barth Ramon Subiros-Funosas Lorena Mendive-Tapia Rodger Duffin Mario A. Shields Jennifer A. Cartwright Sónia Troeira Henriques Jesus Sot Felix M. Goñi Rodolfo Lavilla John A. Marwick Sonja Vermeren Adriano G. Rossi Mikala Egeblad Ian Dransfield Marc Vendrell |
| author_facet | Nicole D. Barth Ramon Subiros-Funosas Lorena Mendive-Tapia Rodger Duffin Mario A. Shields Jennifer A. Cartwright Sónia Troeira Henriques Jesus Sot Felix M. Goñi Rodolfo Lavilla John A. Marwick Sonja Vermeren Adriano G. Rossi Mikala Egeblad Ian Dransfield Marc Vendrell |
| author_sort | Nicole D. Barth |
| collection | DOAJ |
| description | Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imaging of apoptotic cells. |
| first_indexed | 2024-12-14T12:46:14Z |
| format | Article |
| id | doaj.art-7e4b972f90a04057803fb05db7c472e8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:46:14Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7e4b972f90a04057803fb05db7c472e82022-12-21T23:00:46ZengNature PortfolioNature Communications2041-17232020-08-0111111410.1038/s41467-020-17772-7A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosisNicole D. Barth0Ramon Subiros-Funosas1Lorena Mendive-Tapia2Rodger Duffin3Mario A. Shields4Jennifer A. Cartwright5Sónia Troeira Henriques6Jesus Sot7Felix M. Goñi8Rodolfo Lavilla9John A. Marwick10Sonja Vermeren11Adriano G. Rossi12Mikala Egeblad13Ian Dransfield14Marc Vendrell15Centre for Inflammation Research, University of EdinburghCentre for Inflammation Research, University of EdinburghCentre for Inflammation Research, University of EdinburghCentre for Inflammation Research, University of EdinburghCold Spring Harbor LaboratoryCentre for Inflammation Research, University of EdinburghInstitute for Molecular Bioscience, The University of QueenslandInstituto Biofisika (CSIC, UPV/EHU) and Departamento de Bioquímica, Universidad del País VascoInstituto Biofisika (CSIC, UPV/EHU) and Departamento de Bioquímica, Universidad del País VascoLaboratory of Medicinal Chemistry and Institute of Biomedicine U. Barcelona (IBUB), Faculty of Pharmacy, University of BarcelonaCentre for Inflammation Research, University of EdinburghCentre for Inflammation Research, University of EdinburghCentre for Inflammation Research, University of EdinburghCold Spring Harbor LaboratoryCentre for Inflammation Research, University of EdinburghCentre for Inflammation Research, University of EdinburghProgrammed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imaging of apoptotic cells.https://doi.org/10.1038/s41467-020-17772-7 |
| spellingShingle | Nicole D. Barth Ramon Subiros-Funosas Lorena Mendive-Tapia Rodger Duffin Mario A. Shields Jennifer A. Cartwright Sónia Troeira Henriques Jesus Sot Felix M. Goñi Rodolfo Lavilla John A. Marwick Sonja Vermeren Adriano G. Rossi Mikala Egeblad Ian Dransfield Marc Vendrell A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis Nature Communications |
| title | A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis |
| title_full | A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis |
| title_fullStr | A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis |
| title_full_unstemmed | A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis |
| title_short | A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis |
| title_sort | fluorogenic cyclic peptide for imaging and quantification of drug induced apoptosis |
| url | https://doi.org/10.1038/s41467-020-17772-7 |
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