Rad51 recruitment and exclusion of non-homologous end joining during homologous recombination at a Tus/Ter mammalian replication fork barrier.

Rad51 recruitment and exclusion of non-homologous end joining during homologous recombination at a Tus/Ter mammalian replication fork barrier.

Classical non-homologous end joining (C-NHEJ) and homologous recombination (HR) compete to repair mammalian chromosomal double strand breaks (DSBs). However, C-NHEJ has no impact on HR induced by DNA nicking enzymes. In this case, the replication fork is thought to convert the DNA nick into a one-en...

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Bibliographic Details
Main Authors: Nicholas A Willis, Arvind Panday, Erin E Duffey, Ralph Scully
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6067765?pdf=render

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http://europepmc.org/articles/PMC6067765?pdf=render

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