What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites
For some types of synapses the availability of release-ready vesicles is a limiting factor during ongoing activity. Synaptic strength in this case is determined both by the recruitment of such vesicles and the probability of their release during an action potential. Here it is argued that not the av...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-09-01
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| Series: | Frontiers in Synaptic Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00144/full |
| _version_ | 1817968221124296704 |
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| author | Erwin Neher |
| author_facet | Erwin Neher |
| author_sort | Erwin Neher |
| collection | DOAJ |
| description | For some types of synapses the availability of release-ready vesicles is a limiting factor during ongoing activity. Synaptic strength in this case is determined both by the recruitment of such vesicles and the probability of their release during an action potential. Here it is argued that not the availability of vesicles is the limiting factor for recruitment, but rather the availability of specific sites to which vesicles can dock. |
| first_indexed | 2024-04-13T20:06:00Z |
| format | Article |
| id | doaj.art-7e4eeb445868474fa4881df45a9be1f2 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-04-13T20:06:00Z |
| publishDate | 2010-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-7e4eeb445868474fa4881df45a9be1f22022-12-22T02:32:00ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632010-09-01210.3389/fnsyn.2010.001442240What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release SitesErwin Neher0Max-Planck-Institut für biophysikalische ChemieFor some types of synapses the availability of release-ready vesicles is a limiting factor during ongoing activity. Synaptic strength in this case is determined both by the recruitment of such vesicles and the probability of their release during an action potential. Here it is argued that not the availability of vesicles is the limiting factor for recruitment, but rather the availability of specific sites to which vesicles can dock.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00144/fullEndocytosisExocytosissynapsecalyx of heldneurotransmitter releaserelease site |
| spellingShingle | Erwin Neher What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites Frontiers in Synaptic Neuroscience Endocytosis Exocytosis synapse calyx of held neurotransmitter release release site |
| title | What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites |
| title_full | What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites |
| title_fullStr | What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites |
| title_full_unstemmed | What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites |
| title_short | What is Rate-Limiting During Sustained Synaptic Activity: Vesicle Supply or the Availability of Release Sites |
| title_sort | what is rate limiting during sustained synaptic activity vesicle supply or the availability of release sites |
| topic | Endocytosis Exocytosis synapse calyx of held neurotransmitter release release site |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00144/full |
| work_keys_str_mv | AT erwinneher whatisratelimitingduringsustainedsynapticactivityvesiclesupplyortheavailabilityofreleasesites |