Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease

Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease

Abstract Background Parthanatos represents a critical molecular aspect of Parkinson's disease, wherein AIMP2 aberrantly activates PARP-1 through direct physical interaction. Although AIMP2 ought to be a therapeutic target for the disease, regrettably, it is deemed undruggable due to its non-enz...

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Bibliographic Details
Main Authors: Min Hak Lee, Ki-Hwan Um, Seok Won Lee, Ye Ji Sun, Da-Hye Gu, Young Ok Jo, Sung Hyun Kim, Wongi Seol, Hyorin Hwang, Kyunghwa Baek, Jin Woo Choi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Acta Neuropathologica Communications
Subjects:
AIMP2 splicing variants
PARP-1
Parkinson’s disease
Adeno-associated virus
Gene therapy
Online Access:https://doi.org/10.1186/s40478-023-01697-5

Internet

https://doi.org/10.1186/s40478-023-01697-5

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