microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defects. Here, we report that deletion of miR-1-1 result...

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Bibliographic Details
Main Authors: Amy Heidersbach, Chris Saxby, Karen Carver-Moore, Yu Huang, Yen-Sin Ang, Pieter J de Jong, Kathryn N Ivey, Deepak Srivastava
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-11-01
Series:eLife
Subjects:
microRNA-1
cardiac
sarcomere
Telokin
Myocardin
smooth muscle gene expression
Online Access:https://elifesciences.org/articles/01323

Internet

https://elifesciences.org/articles/01323

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