ARHGEF39, a Gene Implicated in Developmental Language Disorder, Activates RHOA and Is Involved in Cell De-Adhesion and Neural Progenitor Cell Proliferation

ARHGEF39, a Gene Implicated in Developmental Language Disorder, Activates RHOA and Is Involved in Cell De-Adhesion and Neural Progenitor Cell Proliferation

ARHGEF39 was previously implicated in developmental language disorder (DLD) via a functional polymorphism that can disrupt post-transcriptional regulation by microRNAs. ARHGEF39 is part of the family of Rho guanine nucleotide exchange factors (RhoGEFs) that activate small Rho GTPases to regulate a w...

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Bibliographic Details
Main Authors: Midas Anijs, Paolo Devanna, Sonja C. Vernes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ARHGEF39
Rho GTPases
RHOA
cell adhesion
scRNA-seq
neural progenitor cells (NPCs)
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.941494/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.941494/full

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