Beyond Amyloid Fibers: Accumulation, Biological Relevance, and Regulation of Higher-Order Prion Architectures

The formation of amyloid fibers is associated with a diverse range of disease and phenotypic states. These amyloid fibers often assemble into multi-protofibril, high-order architectures in vivo and in vitro. Prion propagation in yeast, an amyloid-based process, represents an attractive model to expl...

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Bibliographic Details
Main Authors: Wesley R. Naeimi, Tricia R. Serio
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/14/8/1635