RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge

RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge

ABSTRACT The ongoing COVID-19 pandemic has contributed largely to the global vaccine disparity. Development of protein subunit vaccines can help alleviate shortages of COVID-19 vaccines delivered to low-income countries. Here, we evaluated the efficacy of a three-dose virus-like particle (VLP) vacci...

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Bibliographic Details
Main Authors: Ting Y. Wong, Brynnan P. Russ, Katherine S. Lee, Olivia A. Miller, Jason Kang, Melissa Cooper, Michael T. Winters, Sergio A. Rodriguez-Aponte, Neil C. Dalvie, Ryan S. Johnston, Nathaniel A. Rader, Zeriel Y. Wong, Holly A. Cyphert, Ivan Martinez, Umesh Shaligram, Saurabh Batwal, Rakesh Lothe, Rahul Chandrasekaran, Gaurav Nagar, Meghraj Rajurkar, Harish Rao, Justin R. Bevere, Mariette Barbier, J. Christopher Love, F. Heath Damron
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mSphere
Subjects:
SARS-CoV-2
COVID-19
vaccines
RBD
HBsAg
VLP
Online Access:https://journals.asm.org/doi/10.1128/msphere.00243-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00243-22

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