Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells

Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Of the four molecular subgroups, Group 3 MB is the most aggressive and has the worst prognosis. To understand the origins of chemoresistance involving IL-6/STAT3 signaling, we used in vitro co-culture systems to investigate the...

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Bibliographic Details
Main Authors: Lakshana Sreenivasan, Ling Vicky Li, Pascal Leclair, Chinten James Lim
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
interleukin-6
JAK1
STAT3
medulloblastoma
drug resistance
combination therapy
Online Access:https://www.mdpi.com/2073-4409/11/3/381

Internet

https://www.mdpi.com/2073-4409/11/3/381

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