Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation

Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation

Abstract A large-scale biophysical network model for the isolated striatal body is developed to optimise potential intrastriatal deep brain stimulation applied to, e.g. obsessive-compulsive disorder. The model is based on modified Hodgkin–Huxley equations with small-world connectivity, while the spa...

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Bibliographic Details
Main Authors: Konstantinos Spiliotis, Revathi Appali, Anna Karina Fontes Gomes, Jan Philipp Payonk, Simon Adrian, Ursula van Rienen, Jens Starke, Rüdiger Köhling
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
Neuronal network dynamics
Striatum
Deep brain stimulation (DBS)
Mental disorders
Online Access:https://doi.org/10.1038/s41598-024-69456-7

Internet

https://doi.org/10.1038/s41598-024-69456-7

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