Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.

Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.

Previous studies have shown that MDM2 SNP309 and p53 codon 72 have modifier effects on germline P53 mutations, but those studies relied on case-only studies with small sample sizes. The impact of MDM4 polymorphism on tumor onset in germline mutation carriers has not previously been studied.We analyz...

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Bibliographic Details
Main Authors: Shenying Fang, Ralf Krahe, Guillermina Lozano, Younghun Han, Wei Chen, Sean M Post, Baili Zhang, Charmaine D Wilson, Linda L Bachinski, Louise C Strong, Christopher I Amos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2877078?pdf=render

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http://europepmc.org/articles/PMC2877078?pdf=render

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