Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses

Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses

Abstract Intratumor heterogeneity (ITH) stands as one of the main difficulties in the treatment of colorectal cancer (CRC) as it causes the development of resistant clones and leads to heterogeneous drug responses. Here, 12 sets of patient‐derived organoids (PDOs) and cell lines (PDCs) isolated from...

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Bibliographic Details
Main Authors: Soon‐Chan Kim, Ji Won Park, Ha‐Young Seo, Minjung Kim, Jae‐Hyeon Park, Ga‐Hye Kim, Ja Oh Lee, Young‐Kyoung Shin, Jeong Mo Bae, Bon‐Kyoung Koo, Seung‐Yong Jeong, Ja‐Lok Ku
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Advanced Science
Subjects:
colorectal cancer
drug responses
intratumor heterogeneity
patient‐derived organoid
Online Access:https://doi.org/10.1002/advs.202103360

Internet

https://doi.org/10.1002/advs.202103360

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