1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf

1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf

Soluble epoxide hydrolase (sEH) is an enzyme involved in the metabolism of bioactive lipid signaling molecules. sEH converts epoxyeicosatrienoic acids (EET) to virtually inactive dihydroxyeicosatrienoic acids (DHET). The first acids are “medicinal” molecules, the second increase the inflammatory inf...

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Bibliographic Details
Main Authors: Boris P. Gladkikh, Dmitry V. Danilov, Vladimir S. D’yachenko, Gennady M. Butov
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
soluble epoxide hydrolase (sEH)
cancer
p38 MAPK
inhibitors
signaling pathway
c-Raf
Online Access:https://www.mdpi.com/1422-0067/25/1/338

Internet

https://www.mdpi.com/1422-0067/25/1/338

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