Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific antigens (TSAs). Recent work has shown that gene-...

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Bibliographic Details
Main Authors: Kristen L Wells, Corey N Miller, Andreas R Gschwind, Wu Wei, Jonah D Phipps, Mark S Anderson, Lars M Steinmetz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
single-cell transcriptomics
medullary thymic epithelial cell
immune system
Online Access:https://elifesciences.org/articles/60188

Internet

https://elifesciences.org/articles/60188

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