Diverse target gene modifications in Plasmodium falciparum using Bxb1 integrase and an intronic attB

Diverse target gene modifications in Plasmodium falciparum using Bxb1 integrase and an intronic attB

Abstract Genetic manipulation of the human malaria parasite Plasmodium falciparum is needed to explore pathogen biology and evaluate antimalarial targets. It is, however, aggravated by a low transfection efficiency, a paucity of selectable markers and a biased A/T-rich genome. While various enabling...

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Bibliographic Details
Main Authors: Praveen Balabaskaran-Nina, Sanjay A. Desai
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Parasites & Vectors
Subjects:
Malaria
DNA transfection
Intron
Bxb1 integrase
Gene editing
Online Access:http://link.springer.com/article/10.1186/s13071-018-3129-5

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http://link.springer.com/article/10.1186/s13071-018-3129-5

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