Hyperthermia improves gemcitabine sensitivity of pancreatic cancer cells by suppressing the EFNA4/β-catenin axis and activating dCK

Hyperthermia improves gemcitabine sensitivity of pancreatic cancer cells by suppressing the EFNA4/β-catenin axis and activating dCK

Background: Previously, our investigations have underscored the potential of hyperthermia to improve the therapeutic efficacy of gemcitabine (GEM) in pancreatic cancer (PC). Nonetheless, the precise underlying mechanisms remain elusive. Methods: We engineered two GEM-resistant PC cell lines (BxPC-3/...

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Bibliographic Details
Main Authors: Qiaoxian He, Yangyang Zheng, Lei Lu, Hongzhang Shen, Weigang Gu, Jianfeng Yang, Xiaofeng Zhang, Hangbin Jin
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
Pancreatic cancer
Gemcitabine
Hyperthermia
dCK
EFNA4
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024045195

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http://www.sciencedirect.com/science/article/pii/S2405844024045195

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