Relaxation-Compensated Chemical Exchange Saturation Transfer MRI in the Brain at 7T: Application in Relapsing-Remitting Multiple Sclerosis

Relaxation-Compensated Chemical Exchange Saturation Transfer MRI in the Brain at 7T: Application in Relapsing-Remitting Multiple Sclerosis

Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) can probe tissue biochemistry in vivo with high resolution and sensitivity without requiring exogenous contrast agents. Applying CEST MRI at ultrahigh field provides advantages of increasing spectral resolution and improvi...

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Bibliographic Details
Main Authors: Kristin P. O'Grady, Sanjana Satish, Quinn R. Owen, Bailey A. Box, Francesca Bagnato, Anna J. E. Combes, Sarah R. Cook, Holly James Westervelt, Haley R. Feiler, Richard D. Lawless, Asha Sarma, Shekinah D. Malone, Josephine M. Ndolo, Keejin Yoon, Richard D. Dortch, Baxter P. Rogers, Seth A. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Neurology
Subjects:
chemical exchange saturation transfer (CEST)
glutamate
multiple sclerosis
metabolic imaging
ultrahigh field
apparent exchange-dependent relaxation (AREX)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.764690/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.764690/full

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