Amino acid sites related to the PB2 subunits of IDV affect polymerase activity

Amino acid sites related to the PB2 subunits of IDV affect polymerase activity

Abstract Background In 2011, a new influenza virus, named Influenza D Virus (IDV), was isolated from pigs, and then cattle, presenting influenza-like symptoms. IDV is one of the causative agents of Bovine Respiratory Disease (BRD), which causes high morbidity and mortality in feedlot cattle worldwid...

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Bibliographic Details
Main Authors: Yutian Wang, Weiyang Sun, Zhenfei Wang, Menglin Zhao, Xinghai Zhang, Yunyi Kong, Xuefeng Wang, Na Feng, Tiecheng Wang, Feihu Yan, Yongkun Zhao, Xianzhu Xia, Songtao Yang, Yuwei Gao
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Virology Journal
Subjects:
Influenza D virus
Viral polymerase
PB2 protein
Single-site mutation
Random mutation library
Mini-replicon reporter constructs
Online Access:https://doi.org/10.1186/s12985-021-01703-z

Internet

https://doi.org/10.1186/s12985-021-01703-z

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