Amiodarone, Verapamil, or Diltiazem Use With Direct Oral Anticoagulants and the Risk of Hemorrhage in Older Adults

Amiodarone, Verapamil, or Diltiazem Use With Direct Oral Anticoagulants and the Risk of Hemorrhage in Older Adults

Background: Routinely used cardiac medications, based on pharmacokinetics, are hypothesized to increase drug levels of direct oral anticoagulants (DOACs), with the potential to increase the risk of hemorrhage. We set out to compare the risk for hemorrhage following initiation of amiodarone, verapami...

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Main Authors: Kevin Hill, MD, Ewa Sucha, MSc, Emily Rhodes, MPH, Sarah Bota, MPH, Gregory L. Hundemer, MD, MPH, Edward G. Clark, MD, MSc, Mark Canney, MD, PhD, Ziv Harel, MD, MPH, Tzu-Fei Wang, MD, MSc, Marc Carrier, MD, MSc, Harindra C. Wijeysundera, MD, PhD, Greg Knoll, MD, MSc, Manish M. Sood, MD, MSc
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:CJC Open
Online Access:http://www.sciencedirect.com/science/article/pii/S2589790X21002997

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http://www.sciencedirect.com/science/article/pii/S2589790X21002997

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