A 3’UTR-derived small RNA represses pneumolysin synthesis and facilitates pneumococcal brain invasion

Abstract Pneumolysin (Ply) of Streptococcus pneumoniae (pneumococcus) at relatively high and low levels facilitates pneumococcal invasion into the lung and brain, respectively; however, the regulatory mechanisms of Ply expression are poorly understood. Here, we find that a small RNA plyT, processed...

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Bibliographic Details
Main Authors: Kaiqiang Shen, Wenshuang Miao, Lin Zhu, Qingqing Hu, Fu Ren, Xiuzhu Dong, Huichun Tong
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06845-8