Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators

Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators

Cystic fibrosis (CF) is caused by different mutations related to the cystic fibrosis transmembrane regulator protein (CFTR), with F508del being the most common. Pioneering the development of CFTR modulators, thanks to the development of effective correctors or potentiators, more recent studies deepl...

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Bibliographic Details
Main Authors: Roberto Sabbadini, Emanuela Pesce, Alice Parodi, Eleonora Mustorgi, Santina Bruzzone, Nicoletta Pedemonte, Monica Casale, Enrico Millo, Elena Cichero
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
HSP70
allosteric inhibitor
MKT-077
CFTR modulator
correctors
virtual screening
Online Access:https://www.mdpi.com/1424-8247/14/12/1296

Internet

https://www.mdpi.com/1424-8247/14/12/1296

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