Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies

Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies

Due to the recent advances of atovaquone, a naphthoquinone, through clinical trials as treatment for malarial infection, 19 quinone derivatives with previously reported structures were also evaluated for blood schizonticide activity against the malaria parasite Plasmodium falciparum. These compounds...

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Bibliographic Details
Main Authors: Nicolli Bellotti de Souza, Isabel M de Andrade, Paula F Carneiro, Guilherme AM Jardim, Isadora MM de Melo, Eufrânio N da Silva Júnior, Antoniana Ursine Krettli
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2014-08-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
antimalarials
quinones
phenazines
lapachol
Plasmodium falciparum
Plasmodium berghei
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500546&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500546&lng=en&tlng=en

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