Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc

We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density. Mutagenesis of the Kir6.2 ankyrin binding site disrupts this functional coupling....

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Bibliographic Details
Main Authors: Hua-Qian Yang, Marta Pérez-Hernández, Jose Sanchez-Alonso, Andriy Shevchuk, Julia Gorelik, Eli Rothenberg, Mario Delmar, William A Coetzee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
ATP-sensitive K+ channel
Na+ channel
heart
intercalated disk
channel interactions
Online Access:https://elifesciences.org/articles/52373

Internet

https://elifesciences.org/articles/52373

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