High Serum Vitamin D Concentrations, Induced via Diet, Trigger Immune and Intestinal Microbiota Alterations Leading to Type 1 Diabetes Protection in NOD Mice

High Serum Vitamin D Concentrations, Induced via Diet, Trigger Immune and Intestinal Microbiota Alterations Leading to Type 1 Diabetes Protection in NOD Mice

The hormonally-active form of vitamin D, 1,25-dihydroxyvitamin D3, can modulate both innate and adaptive immunity, through binding to the nuclear vitamin D receptor expressed in most immune cells. A high dose of regular vitamin D protected non-obese diabetic (NOD) mice against type 1 diabetes (T1D),...

Full description

Bibliographic Details
Main Authors: Pieter-Jan Martens, Javier Centelles-Lodeiro, Darcy Ellis, Dana Paulina Cook, Gabriele Sassi, Lieve Verlinden, Annemieke Verstuyf, Jeroen Raes, Chantal Mathieu, Conny Gysemans
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
vitamin D
immunomodulation
gut microbiota
gut permeability
microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.902678/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.902678/full

Similar Items