Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

IntroductionPeople with DS are highly predisposed to Alzheimer’s disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS.MethodsWe undertook studies to characterize age-related changes for AD-re...

Full description

Bibliographic Details
Main Authors: Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker, Andrea Pfeifer, William C. Mobley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neuroscience
Subjects:
DS-AD
animal model
age
Down syndrome
Alzheimer’s disease
tau
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1202208/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1202208/full

Similar Items