Possibility of selection against mtDNA mutations in tumors
<p>Abstract</p> <p>Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2005-09-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://www.molecular-cancer.com/content/4/1/36 |
| _version_ | 1819177756948168704 |
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| author | Reis RJ Shmookler Khaidakov M |
| author_facet | Reis RJ Shmookler Khaidakov M |
| author_sort | Reis RJ Shmookler |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutations in nontumor monoclonal cells suggests that, contrary to the prevailing view, the process of tumorigenesis may be accompanied by active selection against detrimental mtDNA mutations.</p> |
| first_indexed | 2024-12-22T21:31:43Z |
| format | Article |
| id | doaj.art-7e7e98ce9113477688d7c45aa8d51334 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-22T21:31:43Z |
| publishDate | 2005-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-7e7e98ce9113477688d7c45aa8d513342022-12-21T18:11:54ZengBMCMolecular Cancer1476-45982005-09-01413610.1186/1476-4598-4-36Possibility of selection against mtDNA mutations in tumorsReis RJ ShmooklerKhaidakov M<p>Abstract</p> <p>Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutations in nontumor monoclonal cells suggests that, contrary to the prevailing view, the process of tumorigenesis may be accompanied by active selection against detrimental mtDNA mutations.</p>http://www.molecular-cancer.com/content/4/1/36tumorigenesismitochondrial DNAmutations |
| spellingShingle | Reis RJ Shmookler Khaidakov M Possibility of selection against mtDNA mutations in tumors Molecular Cancer tumorigenesis mitochondrial DNA mutations |
| title | Possibility of selection against mtDNA mutations in tumors |
| title_full | Possibility of selection against mtDNA mutations in tumors |
| title_fullStr | Possibility of selection against mtDNA mutations in tumors |
| title_full_unstemmed | Possibility of selection against mtDNA mutations in tumors |
| title_short | Possibility of selection against mtDNA mutations in tumors |
| title_sort | possibility of selection against mtdna mutations in tumors |
| topic | tumorigenesis mitochondrial DNA mutations |
| url | http://www.molecular-cancer.com/content/4/1/36 |
| work_keys_str_mv | AT reisrjshmookler possibilityofselectionagainstmtdnamutationsintumors AT khaidakovm possibilityofselectionagainstmtdnamutationsintumors |