PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two structurally related immunosuppressive peptides. However, the underlying mechanisms through which these peptides regulate microglial activity are not fully understood. Using lipopolysaccharide...

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Bibliographic Details
Main Authors: Jocelyn Karunia, Aram Niaz, Mawj Mandwie, Sarah Thomas Broome, Kevin A. Keay, James A. Waschek, Ghaith Al-Badri, Alessandro Castorina
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
microglial activation
PACAP
VIP
morphological analyses
BV2
inflammatory markers
Online Access:https://www.mdpi.com/1422-0067/22/20/10947

Internet

https://www.mdpi.com/1422-0067/22/20/10947

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