A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson’s Disease

A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson’s Disease

Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain endothelial cells have been used to shuttle antibodies and other cargos across the blood brain barrier (BBB) to the brain. For these studies the TXB4 brain shuttle was fused to a TrkB neurotrophin receptor agonist...

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Bibliographic Details
Main Authors: Emily Clarke, Pawel Stocki, Elizabeth H. Sinclair, Aziz Gauhar, Edward J. R. Fletcher, Alicja Krawczun-Rygmaczewska, Susan Duty, Frank S. Walsh, Patrick Doherty, Julia Lynn Rutkowski
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
TrkB
agonist antibody
variable new antigen receptor (VNAR)
neuroprotection
transferrin receptor 1 (TfR1)
blood-brain barrier (BBB)
Online Access:https://www.mdpi.com/1999-4923/14/7/1335

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https://www.mdpi.com/1999-4923/14/7/1335

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