Investigation of Solubility Behavior of Canagliflozin Hydrate Crystals Combining Crystallographic and Hirshfeld Surface Calculations

Investigation of Solubility Behavior of Canagliflozin Hydrate Crystals Combining Crystallographic and Hirshfeld Surface Calculations

Canagliflozin (CG) was a highly effective, selective and reversible inhibitor of sodium-dependent glucose co-transporter 2 developed for the treatment of type 2 diabetes mellitus. The crystal structure of CG monohydrate (CG-H<sub>2</sub>O) was reported for the first time while CG hemihyd...

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Bibliographic Details
Main Authors: Yefen Zhu, Yanlei Kang, Ling Zhu, Kaxi Yu, Shuai Chen, Guping Tang, Xiurong Hu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
canagliflozin
hemihydrate
monohydrate
crystal structure
solubility
Online Access:https://www.mdpi.com/1420-3049/26/2/298

Internet

https://www.mdpi.com/1420-3049/26/2/298

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