Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation.

BACKGROUND: Regular use of β2-agonists may enhance non-specific airway responsiveness. The wingless/integrated (Wnt) signaling pathways are responsible for several cellular processes, including airway inflammation and remodeling while cAMP-PKA cascade can activate the Wnt signaling. We aimed to inve...

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Bibliographic Details
Main Authors: Christophe Faisy, Stanislas Grassin-Delyle, Sabine Blouquit-Laye, Marion Brollo, Emmanuel Naline, Alain Chapelier, Philippe Devillier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4216012?pdf=render