Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels

Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels

Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneurons in mouse and human. We identify AnkR-associated...

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Bibliographic Details
Main Authors: Sharon R Stevens, Colleen M Longley, Yuki Ogawa, Lindsay H Teliska, Anithachristy S Arumanayagam, Supna Nair, Juan A Oses-Prieto, Alma L Burlingame, Matthew D Cykowski, Mingshan Xue, Matthew N Rasband
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
cytoskeleton
ion channel
perineuronal net
extracellular matrix
spectrin
ankyrin
Online Access:https://elifesciences.org/articles/66491

Internet

https://elifesciences.org/articles/66491

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