D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

Abstract The D-aspartate oxidase (DDO) gene encodes the enzyme responsible for the catabolism of D-aspartate, an atypical amino acid enriched in the mammalian brain and acting as an endogenous NMDA receptor agonist. Considering the key role of NMDA receptors in neurodevelopmental disorders, recent f...

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Bibliographic Details
Main Authors: Barbara Lombardo, Marco Pagani, Arianna De Rosa, Marcella Nunziato, Sara Migliarini, Martina Garofalo, Marta Terrile, Valeria D’Argenio, Alberto Galbusera, Tommaso Nuzzo, Annaluisa Ranieri, Andrea Vitale, Eleonora Leggiero, Anna Di Maio, Noemi Barsotti, Ugo Borello, Francesco Napolitano, Alessandra Mandarino, Marco Carotenuto, Uriel Heresco-Levy, Massimo Pasqualetti, Paolo Malatesta, Alessandro Gozzi, Francesco Errico, Francesco Salvatore, Lucio Pastore, Alessandro Usiello
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02088-5

Internet

https://doi.org/10.1038/s41398-022-02088-5

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