Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Abstract DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional HTT CAG repeat size in two cohorts of individua...

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Bibliographic Details
Main Authors: Karin Dalene Skarping, Larissa Arning, Åsa Petersén, Huu Phuc Nguyen, Samuel Gebre-Medhin
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Huntington disease
Lynch syndrome
Mismatch repair
HTT CAG repeat size
Online Access:https://doi.org/10.1038/s41598-024-54277-5

Internet

https://doi.org/10.1038/s41598-024-54277-5

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