Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation

Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation

Abstract Background CD38+ NK cells are overabundant in rheumatoid arthritis (RA). Cyanidin-3-O-glucoside (C3G) is an inhibitor of CD38. This study investigated the pathogenic role of CD38+ NK cells and the effect of C3G on RA. Methods Rats with bovine type II collagen-induced arthritis (CIA) were in...

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Bibliographic Details
Main Authors: Hongxing Wang, Shutong Li, Guoqing Zhang, Hui Wu, Xiaotian Chang
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Arthritis Research & Therapy
Subjects:
CD38
Cyanidin-3-O-glucoside (C3G)
IFN-γ
IL-10
CD38+ NK cell
Mononuclear cells (MNCs)
Online Access:http://link.springer.com/article/10.1186/s13075-019-2001-0

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http://link.springer.com/article/10.1186/s13075-019-2001-0

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