Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis

Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis

Abstract Background Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to hyaluronan, LYVE-1 can mediate adhesion of leukocytes and cancer cells to endothelial cells. Here, we assessed the imp...

Full description

Bibliographic Details
Main Authors: Anna Sophia Jauch, Sebastian A. Wohlfeil, Céline Weller, Bianca Dietsch, Verena Häfele, Ana Stojanovic, Maximilian Kittel, Hendrik Nolte, Adelheid Cerwenka, Michael Neumaier, Kai Schledzewski, Carsten Sticht, Philipp-Sebastian Reiners-Koch, Sergij Goerdt, Cyrill Géraud
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cancer Cell International
Subjects:
Lyve-1
Liver
Immune microenvironment
Liver homeostasis
Liver metastasis
Online Access:https://doi.org/10.1186/s12935-022-02800-x

Internet

https://doi.org/10.1186/s12935-022-02800-x

Similar Items