Increased Formation of Follicular Antrum in Aquaporin-8-Deficient Mice Is Due to Defective Proliferation and Migration, and Not Steroidogenesis of Granulosa Cells

Increased Formation of Follicular Antrum in Aquaporin-8-Deficient Mice Is Due to Defective Proliferation and Migration, and Not Steroidogenesis of Granulosa Cells

Aquaporin-8 (AQP8) is a water channel protein expressed exclusively in granulosa cells (GCs) in mouse ovary. Our previous studies of AQP8-deficient (AQP8-/-) mice demonstrated that AQP8 participates in folliculogenesis, including in the formation of follicles, ovulation, and atresia. However, its ph...

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Bibliographic Details
Main Authors: Dejiang Wang, Xiangjun Di, Jie Wang, Miao Li, Di Zhang, Yaxin Hou, Jiao Hu, Ge Zhang, He Zhang, Meiyan Sun, Xiangyu Meng, Bo Sun, Chunlai Jiang, Tonghui Ma, Weiheng Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
aquaporin-8
granulosa cells
folliculogenesis
antral follicle
cell proliferation
cell migration
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01193/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01193/full

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