1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) Signaling Capacity and the Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer (NSCLC): Implications for Use of 1,25(OH)2D3 in NSCLC Treatment

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) Signaling Capacity and the Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer (NSCLC): Implications for Use of 1,25(OH)2D3 in NSCLC Treatment

1,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts anti-proliferative activity by binding to the vitamin D receptor (VDR) and regulating gene expression. We previously reported that non-small cell lung cancer (NSCLC) cells which harbor epidermal growth factor receptor (EGFR) mutations display elevated VD...

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Bibliographic Details
Main Authors: Pamela A. Hershberger, Song Liu, Moray Campbell, Maochun Qin, Suzanne Shoemaker, Alissa Verone, Santosh Kumar Upadhyay
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Cancers
Subjects:
epithelial mesenchymal transition
vitamin D
1,25-dihydroxyvitamin D3
lung cancer, TGFβ
Online Access:http://www.mdpi.com/2072-6694/5/4/1504

Internet

http://www.mdpi.com/2072-6694/5/4/1504

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